Registration Dossier
Registration Dossier
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EC number: 824-801-7 | CAS number: 1093628-27-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In order to predict effects of chemicals in the environment and in biological waste water treatment plants, an activated sludge respiration inhibition test was performed. The toxicity
to activated sludge was determined in accordance with OECD Test Guideline 209, and in compliance with the OECD principles of Good Laboratory Practice.
The test is valid as shown by the EC50 of the reference compound 3,5-dichlorophenol (12 mg/L) and the coefficient of variation of the replicates of the control oxygen uptake rates
(9%). The average oxygen uptake rate for the control replicates is lower (16 mg O2/g dry weight/hour) than the prescribed rate (>20 mg O2/g dry weight /hour). This does not
influence the sensitivity of the activated sludge as shown by comparable EC50 values of the reference substance 3,5-dichlorophenol at oxygen uptake rates lower and higher than the
prescribed rate (AkzoNobel 2012). The lower average oxygen uptake rate does therefore not compromise the test outcome in terms of robustness of the endpoints obtained for the
test and reference substance and does not invalidate the test.
The toxicity of benzenesulfonic acid, C10-13-alkyl derivs., compds. with N,N-dimethyl-1,3 -propanediamine to activated sludge was determined at a contact time of 3 hours, using
various concentrations of the test substance. The inhibitory effect of benzenesulfonic acid, C10-13-alkyl derivs., compds. with N,N-dimethyl-1,3-propanediamine at a particular
concentration is expressed as a percentage of the two controls. From the results EC values were calculated. The EC50 of benzenesulfonic acid, C10-13-alkyl derivs., compds. with N,Ndimethyl- 1,3-propanediamine for activated sludge after 3 hours contact time is 200 mg/L with 95% confidence limits of 139 and 318 mg/L. The EC10 and EC80 values could not be
determined and the EC20 is 25 mg/L. Benzenesulfonic acid, C10-13-alkyl derivs., compds. with N,N-dimethyl-1,3-propanediamine is therefore considered not harmful to activated
sludge.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 200 mg/L
Additional information
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