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Short-term toxicity to aquatic invertebrates

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Description of key information

The acute toxicity of Witconate P-1460 to Daphnia magna (water flea) was tested under static conditions for 48 hours in accordance with OECD 202 and EEC C.2 guidelines for testing chemicals, and ECETOC, Monograph 26 (1996). The test was performed in compliance with Good Laboratory Practice (GLP).

Witconate P-1460 is miscible in water. A preliminary test showed that Witconate P-1460 had a 100% toxicity effect at a test concentration 10 mg/L and an observed NOEC of 1 mg/L having slightly sub lethal effects. Therefore a toxicity test was performed exposing D. magna to a series of test concentrations respectively 0.5, 1.1, 2.3, 4.9 and 10.2 mg/L of test substance.

The results of the definitive test show that the test substance had effect on the mobility of D. magna.

The NOEC and the LOEC (0-48h) of Witconate P-1460 are 2.3 mg/L and 4.9 mg/L respectively. EC50 and EC100 values of respectively 3.6 mg/L (3.3 - 4.0, 95% confidence limits) and 10.2 mg/L were determined. No further sub-lethal effects were observed in the test concentrations where no immobility was observed. The results of the chemical analyses show that the average observed test substance concentrations during the test differs less than 20% from the nominal test concentrations. The results are therefore presented based on their nominal test concentrations.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
3.6 mg/L

Additional information