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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Safety Evaluation of Selenium Sulfide Antidandruff Shampoos
Author:
LAURENCE M., CUMMINS AND EUGENE T. KIMURA
Year:
1971
Bibliographic source:
TOXICOLOGY AND APPLIED PHARMACOLOGY 20,89-96 (1971)

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-Benzyl-N,N-dimethyl-1-tridecanaminium chloride
Cas Number:
8001-54-5
Molecular formula:
C22H40ClN
IUPAC Name:
N-Benzyl-N,N-dimethyl-1-tridecanaminium chloride

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
methylcellulose
Doses:
0.1 to 20%
No. of animals per sex per dose:
6 rats per dose, 30 to 36 rats total
Control animals:
not specified
Details on study design:
7-10 days observation following treatment
Statistics:
95% CL, Litchfield and Wilcoxon (1949)

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 400 mg/kg bw
Based on:
act. ingr.
95% CL:
>= 342 - <= 469
Mortality:
not specified
Clinical signs:
not specified
Body weight:
between 50 and 100 g
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Administration of benzalkonium chloride in 30 to 36 Sprague-Dawley rats by oral route: LD50 of 400 mg/kg bw.
Executive summary:

Administration of benzalkonium chloride in Sprague-Dawley rats by oral route: LD50 of 400mg/kg