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Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 Feb - 3 Mar 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
static method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 116B2018
- Physical state: clear and colorless liquid
- Analytical purity: 96.3%
- Expiration date of the lot/batch: 31 August 2018
- Purity test date: 15 Nov 2016

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature container flushed with nitrogen
Key result
Temp.:
20 °C
Vapour pressure:
4 700 Pa
Remarks on result:
other: 35 mm Hg
Temp.:
25 °C
Vapour pressure:
6 000 Pa
Remarks on result:
other: 45 mm Hg

Linear regression analysis of the log P(T) values and 1/T was performed using a least squares method. The vapor pressure of the test substance at 20 °C and 25 °C were determined using the vapour pressure regression curve. The equation of the curve was: log P(T) = -1803 ×1/T + 9.82 (r = 0.9997, n = 18).

Conclusions:
The vapor pressure of PPVE-2 is 4.7E03 Pa (35 mm Hg) at 20 °C and 6.0E03 Pa (45 mm Hg) at 25 °C as determined by EU Method A.4.
Executive summary:

The vapor pressure of the test substance was determined by the static method. The vapor pressure of the test item at 5 °C intervals from 40 °C to 80 °C was determined and entered into linear regression. The resulting equation was log P(T) = -1803 ×1/T + 9.82 (r = 0.9997). The test was done according to EU Method A.4 and in accord with GLP guidelines; therefore the study is considered reliable without restriction.

Endpoint:
vapour pressure
Type of information:
not specified
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Qualifier:
no guideline followed
GLP compliance:
no
Key result
Temp.:
20 °C
Vapour pressure:
4 079.7 Pa
Remarks on result:
other: (30.6 mm Hg)
Conclusions:
A vapor pressure of 4079.7 Pa (30.6 mm Hg) at 20 °C was reported for PPVE-2.
Executive summary:

A vapor pressure of 4079.7 Pa (30.6 mm Hg) at 20 °C was reported for PPVE-2. Only the result was reported on the SDS and no information about the method used was provided; therefore the reliability of the data is not assignable.

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Qualifier:
no guideline available
GLP compliance:
no
Type of method:
dynamic method
Key result
Temp.:
20 °C
Vapour pressure:
3 060 Pa
Remarks on result:
other: 23 mm Hg

 T (°C) P (hPa) 
 24.3 39.4 
 37.6 80.5 
 50.5 151.2 
 66.7 300.3
 79.9 500.2 
 89.5  700.0

Antoine equation:

log P(hPa) = A + B/(C + T(°C))

A = 7.03056

B = -1186.561

C = 194

Conclusions:
A vapor pressure of 3060 Pa at 20 °C was reported for PPVE-2 by a dynamic method.
Executive summary:

A dynamic method was used to test the vapor pressure of PPVE-2. A result of 3060 Pa at 20 °C was included in the report. The study did not list testing lab, guideline, nor GLP compliance. No information is available on test substance composition; therefore, the documentation is insufficient for assessment.

Description of key information

The vapor pressure of PPVE-2 is 4.7E03 Pa (35 mm Hg) at 20 °C and 6.0E03 Pa (45 mm Hg) at 25 °C as determined by EU Method A.4.

Key value for chemical safety assessment

Additional information

In the key study, the vapor pressure of the test substance was determined by the static method. The vapor pressure of the test item at 5 °C intervals from 40 °C to 80 °C was determined and entered into linear regression. The resulting equation was log P(T) = -1803 ×1/T + 9.82 (r = 0.9997). The test was done according to EU Method A.4 and in accord with GLP guidelines; therefore the study is considered reliable without restriction. In one supporting study, a dynamic method was used to test the vapor pressure of PPVE-2. A result of 3060 Pa at 20 °C was included in the report. The study did not list testing lab, guideline, nor GLP compliance. No information is available on test substance composition; therefore, the documentation is insufficient for assessment. In another supporting study, a vapor pressure of 4079.7 Pa (30.6 mm Hg) at 20 °C was reported for PPVE-2. Only the result was reported on the SDS and no information about the method used was provided; therefore the reliability of the data is not assignable.