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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and sufficient documented

Data source

Reference
Reference Type:
publication
Title:
Fetal toxicity of zinc ethylphenylditioncarbamate (ZEPC) (3.). Mechanism of formation of methemoglobin caused by ZEPC
Author:
Nakaura S, Kawanishi T, Ohno Y, Kawashima K, Tanaka S, Takahashi S, Takanaka A, Omori Y, Matumoto K
Year:
1985
Bibliographic source:
J Toxicol Sci 10, 252

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
After oral administration of 1000 mg/kg of ZEPC to Wistar rats female rats, the metabolites in the blood were extracted with ethyl acetate.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Zinc bis(N-ethyl-N-phenyldithiocarbamate)
EC Number:
238-677-1
EC Name:
Zinc bis(N-ethyl-N-phenyldithiocarbamate)
Cas Number:
14634-93-6
Molecular formula:
C18H20N2S4Zn
IUPAC Name:
zinc bis(N-ethyl-N-phenyldithiocarbamate)
Specific details on test material used for the study:
No data.
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on exposure:
No data
Duration and frequency of treatment / exposure:
No data
Doses / concentrations
Dose / conc.:
1 000 mg/kg bw/day (nominal)
No. of animals per sex per dose / concentration:
No data
Control animals:
not specified
Positive control reference chemical:
No data
Details on study design:
Metabolites in the blood were extracted with ethyl acetate and identified by GC-MS.

Results and discussion

Main ADME results
Type:
metabolism
Results:
N-ethylaniline and Aniline were identified as metabolites

Toxicokinetic / pharmacokinetic studies

Details on absorption:
No data
Details on distribution in tissues:
No data
Details on excretion:
No data

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
N-ethylaniline and Aniline were identified as metabolites.

Applicant's summary and conclusion

Conclusions:
N-ethylaniline and Aniline were idetified as metabolites.
Executive summary:

After oral adminisatration of 1000 mg/kg of ZEPC to Wistar rats female rats, the metabolites in the blood were extracted with ethyl acetate. N-ethylaniline (N-EA) and Aniline (AN) were identified as metabolites. N-EA and AN concentrations in the blood reached maximum levels (10.0 and 2.01 µg/ml) after 24 hr and then decreased to less than 0.3 µg/ml within 3 days. The increased methemoglobin levels in the blood after administration of ZEPC were nearly proportional to the changes in blood concentrations.