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Environmental fate & pathways

Biodegradation in water: screening tests

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Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1991
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Study reviewers stated, "Reliable with restrictions [Klimisch reliability 2]. No information was indicated for number of replicates used in study.".
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
Deviations:
not specified
GLP compliance:
not specified
Specific details on test material used for the study:
Purity was 95%
Oxygen conditions:
aerobic
Inoculum or test system:
activated sludge (adaptation not specified)
Details on inoculum:
No further information was given.
Duration of test (contact time):
ca. 28 d
Parameter followed for biodegradation estimation:
DOC removal
Reference substance:
other: Positive control: mineral nutrient soln + inoculum + sodium benzoate (at DOC of 20 mg /L)
Reference substance:
benzoic acid, sodium salt
Preliminary study:
none specified.
Key result
Parameter:
% degradation (DOC removal)
Value:
ca. 98
Sampling time:
28 d
Results with reference substance:
none specified.

Biodegradaton Results

 

% Biodegradation (% of DOC)

Day

0

7

14

21

28

Test Substance

0

49

72

92

98

Positive Control (sodium benzoate)

0

91

91

90

100

Validity criteria fulfilled:
not specified
Interpretation of results:
other:
Remarks:
biodegradable, but not enough samples were taken to determine whether the test material met the 10-day window criteria for readily biodegradable classification.
Conclusions:
Biodegradation was 98% in 28 days for the test material.

1

Description of key information

The read-across chemical heptanoic acid, oxybis(2,1 -ethanediyloxy-2,1 -ethanediyl)ester (CAS 70729 -68 -9) underwent ca. 98% degradation based on DOC removal in a 28 day period. There were insufficient data points taken to determine if the 10 -day window requirement was fulfilled.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable but failing 10-day window
Type of water:
freshwater

Additional information

The test substance is a member of a category of aliphatic esters submitted by The American Chemistry Council's (ACC) Aliphatic Esters Panel (Panel) under the High Production Volume (HPV) Chemical Challenge Program (ACC, 2003). Information from a Screening Information Data Set (SIDS) developed in that program serves as supplementary or weight-of-evidence in the current dossier. Category ester compounds with similar structures and functionalities were readily biodegradable in standard aerobic biodegradation tests. These materials included ethane-1,2 -diylbis(oxyethane-2,1 -diyl) bisheptanoate (CAS 7434 -40 -4), heptanoic acid, oxybis(2,1 -ethanediyloxy-2,1 -ethanediyl)ester (CAS 70729 -68 -9), and heptanoic acid, ester with 2,2,4 -trimethyl-1,3 -pentanediol (CAS 71839 -38 -8.