Registration Dossier
Registration Dossier
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EC number: 910-427-2 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The target substance Zinc peroxide and the source substances Zinc oxide, Zinc Chloride, Zinc sulfate, Zinc nitrate are ionic and consist of the Zinc2+ cation and the respective anion.
The read-across is based on the assumption that the zinc cation (as measure for dissolved zinc species) is the determining factor for (eco)toxicity.
For further details, see Justification for read-across attached to IUCLID chapter 13
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See Justification for read-across attached to IUCLID chapter 13
3. ANALOGUE APPROACH JUSTIFICATION
See Justification for read-across attached to IUCLID chapter 13
4. DATA MATRIX
See Justification for read-across attached to IUCLID chapter 13 - Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 112 - <= 23 060 µg/L
- Nominal / measured:
- not specified
- Conc. based on:
- other: Zn2+
- Basis for effect:
- mortality (fish)
- Conclusions:
- The LC50 values for Zn2+ ranged from 112 µg/L to 23.06 mg/L
Reference
Description of key information
Key data (lowest LC50 values) are:
-for Oncorrhynchus Mykiss: 0.169 mg Zn/l (single value) at neutral/high pH and low hardness
-for Pimephales promelas (single values) : 0.780 mg Zn/l at low pH (high hardness) and 0.330 mg Zn/l at neutral/high pH, high hardness
-for Pimephales promelas: LC50 0.780 mg Zn/l (at low pH); 0.33mg Zn/l at neutral/high pH
Key value for chemical safety assessment
Additional information
Good quality and relevant data for 5 species. Tests were done according to standard protocol or equivalent.
Data are grouped per species according to
-pH: low (6 -<7) - neutral/high (7 -8.5)
-and hardness: low/medium (<100mg CaCO3/l) and medium/high (>100 mg CaCO3/l).
Fish are generally less sensitive than invertebrates and algae.
The available data on hydrogen peroxide show, that Zn2+ is the determining factor for ecotoxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
