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EC number: 309-011-8
CAS number: 99688-45-6
Time after decontamination
OVERALL MEAN: 0.7
OVERALL MEAN: 0.0
The mean has been
calculated using the day 1, 2 & 3 values
Testing for primary dermal
irritation provides information on the irritant effect of the test
substance on the skin following a single dermal application and serves
as a basis for classification and labelling.
The present study was
conducted in compliance with:
-EEC Directive B.4. 'Acute
toxicity Skin Irritation' of the Directive 84/449/EEC: Commission
Directive of 25 April 1984 adapting to technical progress for the sixth
time Council Directive 67/548/EEC on the approximation of the laws,
regulations and administrative provisions relating to the
classification, packaging and labelling of dangerous substances
-OECD Guidelines for Testing
of Chemicals, 404 "Acute Dermal Irritation/Corrosion", OECD 1981
Updated guideline, adopted:
17th July 1992
-The study was conducted in
compliance with the Principles of Good Laboratory Practice Annex of
paragraph 19a, section 1 of the chemical law from August 1990
About 24 hours before the
start of the study the hair in the dorsal region of the body of 3
rabbits was removed with an electric clipper over an area of about 25 cm2.
Only animals with intact skin were used.
Each animal was treated with
0.5 g lndanthren-Oliv HT Colloisol pasted with 0.3 ml isotonic saline.
The substance was applied over the whole surface of a 2.5 x 2.5 cm
cellulose patch on a piece of surgical plaster (specially produced by
Beiersdorf AG, Hamburg). The plaster was fixed to the prepared skin area
and then covered with a semi-occlusive bandage.
The exposure period was 4
hours. After the exposure period all remnants of the test substance were
carefully removed from the skin with warm tap water.
Examinations of the skin
took place after 30 - 60 minutes, and 24, 48 and 72 hours after removal
of the patches.
From 30 minutes up to 24
hours after removal of the patches the treated skin ofall
animals showed very slight up to moderately strong erythema as well as
up to 48 hours p.a. a barely perceptible erythema in one animal.
72 hours after removal of
the patches the irritations were reversible.
Based on the results of this
study lndanthren-Oliv HT Colloisol is slightly irritating to skin.
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