Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Schering AG, Wikrstoffbetrieb F Bergkamen, 61703003
Key result
Water solubility:
> 546 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
1.05 other: mg/mL
Incubation duration:
4 d
Temp.:
20 °C
pH:
8.6

The solubility was determined using the flask method which is based on suspending of the test substance in the solvent until saturation is reached. However in the present case no saturation was reached after addition of approx. 520 mg substance to approx. 1 mL water. At this concentration the addition was finished and the solution was equilibrated at 20°C. The concentration of the solution was monitored by HPLC and the obtained concentrations were corrected by the density of the solution. The results are given in Table 1. The pH value of the aqueous solution was determined to be 8.6.

 

t(days)

c20°C-A (mg/mL)

c20°C-B (mg/mL)

δA (mg/mL)

δB (mg/mL)

S20°C-A(mg/mL)

S20°C-B (mg/mL)

4

448.6

426.7

1259.6

1246.5

553.1

539.3

 

t:samplingtime,timefromstartoftheexperimentat20°C

c20°C-A/c20°C-B:measuredconcentrationoftheclearsolutionofexperimentsAandB

δA/δB:measureddensityofthesolutionofexperimentsAandB

S20°C-A/S20°C-B:solubility(concentrationcorrectedbydensity)ofexperimentsAandB

 

Averaging the values of both series of experiments gives the following water solubility at 20°C with 95 % confidence interval: S20°C > 546 g/L.

Conclusions:
The water solubility of the test item was determined using the flask method. At 20°C no saturation was reached and therefore only a lower limit for the solubility can be given: S20°C > 546 g/L. Consequently the substance is at least highly soluble according to USP (currently USP 25) and EP (currently EP 4th ed.).The pH value of the aqueous solution was 8.6.
Executive summary:

The water solubility of the test item was determined using the flask method. At 20°C no saturation was reached and therefore only a lower limit for the solubility can be given: S20°C > 546 g/L. Consequently the substance is at least highly soluble according to USP (currently USP 25) and EP (currently EP 4th ed.).The pH value of the aqueous solution was 8.6.

Description of key information

The water solubility of the test item was determined using the flask method. At 20°C no saturation was reached and therefore only a lower limit for the solubility can be given: S20°C > 546 g/L. Consequently the substance is at least highly soluble according to USP (currently USP 25) and EP (currently EP 4th ed.).The pH value of the aqueous solution was 8.6.

Key value for chemical safety assessment

Water solubility:
546 g/L
at the temperature of:
20 °C

Additional information