Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
review article or handbook
Title:
Aliphatic Carboxylic Acids
Author:
Katz, G.V. and Guest, D.
Year:
1994
Bibliographic source:
cited in: Patty"s Industrial Hygiene and Toxicology (G.D. Clayton, F.E. Clayton, eds.), Vol. II, Part E, 3523-3671, John Wiley & Sons, N.Y., 1994

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Linoleic acid
EC Number:
200-470-9
EC Name:
Linoleic acid
Cas Number:
60-33-3
Molecular formula:
C18H32O2
IUPAC Name:
octadeca-9,12-dienoic acid
Test material form:
liquid

Test animals

Species:
guinea pig
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
other: depilated
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
24 h

Results and discussion

In vivo

Results
Irritation parameter:
other: visual inspection
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
not determinable because of methodological limitations

Applicant's summary and conclusion

Interpretation of results:
other: No irritation expected under normal exposure conditions. Animals in this test were exposed for 24 hours under an occlusive dressing und only showed slight irritation.