Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
review article or handbook
Title:
Aliphatic Carboxylic Acids
Author:
Katz, G.V. and Guest, D.
Year:
1994
Bibliographic source:
cited in: Patty"s Industrial Hygiene and Toxicology (G.D. Clayton, F.E. Clayton, eds.), Vol. II, Part E, 3523-3671, John Wiley & Sons, N.Y., 1994

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
guinea pig
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
other: depilated
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
24 h

Results and discussion

In vivo

Results
Irritation parameter:
other: visual inspection
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
not determinable because of methodological limitations

Applicant's summary and conclusion

Interpretation of results:
other: No irritation expected under normal exposure conditions. Animals in this test were exposed for 24 hours under an occlusive dressing und only showed slight irritation.