Registration Dossier
Registration Dossier
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EC number: 945-453-3 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The target substance MCHAmix (EC 943 -517 -5) is acutely harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 31.8 mg/L
Additional information
There are no experimental data on the acute toxicity of the reaction product of 2,4-Dinitrotoluene and 2.6-Dinitrotoluene and hydrogen, deaminated (MCHAmix, EC 943-517-5). Therefore, read-across approach was applied to 2-Methylcyclohexylamine (CAS 7003-32-9), which is one of the representative constituents of MCHAmix (EC 939-489-9) and to 2,6-dimethylcyclohexylamine (CAS 6850-63-1) which is a structurally similar chemical.
The source substance 2,6-dimethylcyclohexylamine (CAS 6850-63-1) has a 96 -h LC50 value of 31.8 mg/L (nominal, not pH-adjusted). This study was performed according to German National Standard DIN 38412, part 15 which is similar to OECD Guideline 203. Test conditions were static without analytical verification of the test concentrations, but the substance is considered to be stable in water due to its high water solubility, its moderate vapor pressure and its low Henry's Law Constant. Test species was Leuciscus idus.
A delayed toxic effect was observed when the fish were exposed to a pH-adjusted sample (100 mg/L; BASF AG, 1987, Rep. no.: 10F0267/875102). However, the mortality was the same after 96 h (= 100%).
This study was selected as key study based on the lower LC50.
The constituent 2-Methylcyclohexylamine (CAS 7003-32-9) has a 96 -h LC50 value of 35.1 mg/L (measured; not-pH adjusted) in a static study performed, according to OECD Guideline 203. Danio rerio was used as test species (BASF AG, 1987, rep. no.: 17F0062/965017).
Based on the available experimental information from the read-across, MCHAmix (EC 945-517-5) is considered to be acutely harmful to fish.
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