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EC number: 228-193-9 | CAS number: 6163-58-2
The objective of this study was to evaluate the eye hazard potential of Tri-o-tolylphosphine as measured by its ability to induce opacity and increase permeability in an isolated bovine cornea using the Bovine Corneal Opacity and Permeability test (BCOP test). This report describes the potency of chemicals to induce serious eye damage using isolated bovine corneas. The eye damage of Tri-o-tolylphosphine was tested through topical application for approximately 240 minutes. The study procedures described in this report were based on the most recent OECD guideline. Batch B64002 (Pfizer Lot no. 2000850599) of Tri-o-tolylphosphine was an off-white crystalline powder. Since no workable suspension in physiological saline could be obtained, the test item was used as delivered and added pure on top of the corneas.
The negative control responses for opacity and permeability were less than the upper limits of the laboratory historical range indicating that the negative control did not induce irritancy on the corneas. The mean in vitro irritancy score of the positive control (20% (w/v) Imidazole)
was 147 and within two standard deviations of the current historical positive control mean. It was therefore concluded that the test conditions were adequate and that the test system functioned properly. Tri-o-tolylphosphine did not induce ocular irritation through both endpoints, resulting in a mean in vitro irritancy score of -1.7 after 4 hours of treatment. In conclusion, since Tri-o-tolylphosphine induced an IVIS ≤ 3, no classification is required for eye irritation or serious eye damage.
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