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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Toxicology and Applied Pharmacology. Vol. 1, Pg. 42, 1959.
Year:
1959
Bibliographic source:
ChemID Data Source

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Mepyramine maleate
EC Number:
200-422-7
EC Name:
Mepyramine maleate
Cas Number:
59-33-6
Molecular formula:
C17H23N3O.C4H4O4
IUPAC Name:
N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine but-2-enedioate
Test material form:
solid: particulate/powder

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
513 mg/kg bw

Applicant's summary and conclusion

Conclusions:
LD50 oral (rat): 513mg/kg