Registration Dossier
Registration Dossier
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EC number: 203-523-4 | CAS number: 107-83-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro, other
- Remarks:
- bacteria, mammalian cells
- Type of information:
- other: data from collection of data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- N-hexane
- EC Number:
- 203-777-6
- EC Name:
- N-hexane
- Cas Number:
- 110-54-3
- Molecular formula:
- C6H14
- IUPAC Name:
- hexane
- Test material form:
- liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix from livers of male rats or Syrian hamsters
- Test concentrations with justification for top dose:
- up to 1000µg/plate
- Details on test system and experimental conditions:
- pre-incubation test
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Key result
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Key result
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
Any other information on results incl. tables
In other experiments in vitro (with Escherichia coli, Bacillus subtilis, Salmonella typhimurium or Saccharomyces cerevisiae, as well as in the Chinese hamster cells) no genetic toxicity was found.
In the CHO-test sister chromatid exchange in the fraction with S9 -mix was reported, but no dose-response appeared.
Applicant's summary and conclusion
- Conclusions:
- No in vitro toxicity found in assays using bacterial cells.
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