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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Based on read-across from DMPT, DMDS is considered not a skin or eye irritant.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
see attached justification
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across source
Species:
rabbit
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
4 h
Observation period:
14 days
Number of animals:
6
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
1.72
Max. score:
4
Reversibility:
fully reversible within: Day 14
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
0.22
Max. score:
4
Reversibility:
fully reversible within: Day 10
Irritant / corrosive response data:
see table below
Rabbit # Time [h] Erythema Oedema
1 24 2 0
  48 2 0
  72 2 0
  average 2.0 0.0
2 24 1 0
  48 2 2
  72 1 2
  average 1.3 1.3
3 24 1 0
  48 3 0
  72 2 0
  average 2.0 0.0
4 24 1 0
  48 2 0
  72 1 0
  average 1.3 0.0
5 24 1 0
  48 1 0
  72 1 0
  average 1.0 0.0
6 24 2 0
  48 3 0
  72 3 0
  average 2.7 0.0
Time [h] Erythema Oedema
average 24 1.33 0.00
score 48 2.17 0.33
72 1.67 0.33
24+48+72 1.72 0.22
Interpretation of results:
GHS criteria not met
Conclusions:
Based on read-across from DMPT, DMDS is not considered a skin irritant.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
see attached justification
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across source
Species:
rabbit
Strain:
New Zealand White
Amount / concentration applied:
0.1 mL
Duration of treatment / exposure:
Rinsing after 24 h
Observation period (in vivo):
21 days
Number of animals or in vitro replicates:
6 males
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
1.56
Max. score:
3
Reversibility:
fully reversible within: Day 10
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
see table below

Rabbit # Time [h] cornea iris conjunctivae  
        redness chemosis
1 24 0 0 2 0
  48 0 0 2 0
  72 0 0 2 0
  average 0.0 0.0 2.0 0.0
2 24 0 0 3 0
  48 0 0 1 0
  72 0 0 2 0
  average 0.0 0.0 2.0 0.0
3 24 0 0 2 0
  48 0 0 1 0
  72 0 0 2 0
  average 0.0 0.0 1.7 0.0
4 24 0 0 3 0
  48 0 0 1 0
  72 0 0 0 0
  average 0.0 0.0 1.3 0.0
5 24 0 0 1 0
  48 0 0 1 0
  72 0 0 1 0
  average 0.0 0.0 1.0 0.0
6 24 0 0 2 0
  48 0 0 1 0
  72 0 0 1 0
  average 0.0 0.0 1.3 0.0
       
  Time [h] cornea iris conjunctivae  
        redness chemosis
average 24 0.00 0.00 2.17 0.00
score 48 0.00 0.00 1.17 0.00
  72 0.00 0.00 1.33 0.00
  24+48+72 0.00 0.00 1.56 0.00
Interpretation of results:
GHS criteria not met
Conclusions:
Based on read-across from DMPT, DMDS is not considered an eye irritant.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification