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EC number: 936-118-2 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27.10. - 02.11.2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- column elution method
- Key result
- Water solubility:
- < 26.6 µg/L
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- The preliminary test showed that the water solubility of the test item is < 10 mg/l. According to the preliminary test the water solubility was determined by the column elution method in the main test.
- Conclusions:
- The water solubility cs of the test item was found to be below the quantification limit: cs < 26.6 µg/l.
- Executive summary:
The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis. Two identical samples were prepared, one of them was exposed to a flow rate of 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). After measurement of the volume, pH and temperature, the fractions were subjected to HPLC analysis.
The water solubility cs of the test item was found to be below the quantification limit: cs < 26.6 µg/l
Reference
Column 1:
Rotation period of the fraction collector: 90 min per fraction
Duration of sampling: about 48 h (32 fractions)
Table 1: Column elution method, column 1 (approximately 12.5 ml/h)
Fraction no. |
V / ml |
pH |
water solubility / µg/l |
21 |
20.0 |
6.8 |
<26.6 |
22 |
20.0 |
6.5 |
<26.6 |
23 |
20.0 |
6,4 |
<26.6 |
24 |
20.0 |
6.5 |
<26.6 |
25 |
20.0 |
6.3 |
<26.6 |
The water solubility was found to be below the quantification limit of 26.6 µg/l.
Column 2:
Rotation period of the fraction collector: 45 min per fraction
Duration of sampling: about 48 h (64 fractions)
Table 2: Column elution method, column 2 (approximately 25.0 ml/h)
Fraction no. |
V / ml |
pH |
water solubility / µg/l |
45 |
17.0 |
6.3 |
<26.6 |
46 |
17.0 |
6.3 |
<26.6 |
47 |
17.0 |
6.7 |
<26.6 |
48 |
17.0 |
6.9 |
<26.6 |
49 |
17.0 |
6.4 |
<26.6 |
The water solubility was found to be below the quantification limit of 26.6 µg/l.
In both columns the concentration of five consecutive fractions was constant within ± 30 %. No increasing or decreasing tendency was observed.
Description of key information
The water solubility cs of the test item was found to be below the quantification limit: cs < 26.6 µg/l (reference 4.8-1).
Key value for chemical safety assessment
Additional information
The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis. Two identical samples were prepared, one of them was exposed to a flow rate of 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). After measurement of the volume, pH and temperature, the fractions were subjected to HPLC analysis.
The water solubility cs of the test item was found to be below the quantification limit: cs < 26.6 µg/l
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