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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26 July 2016 to 23 April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Purity: 96.6%
- Description: yellow viscous liquid
Analytical method:
high-performance liquid chromatography
Key result
Type:
Pow
Partition coefficient:
> 0
Temp.:
30 °C
pH:
6.92
Key result
Type:
log Pow
Partition coefficient:
> 9.4
Temp.:
30 °C
pH:
6.92

The result from the preliminary test indicated that the HPLC method was suitable for determination of partition coefficient for this test item.

Due to the high partition coefficient of the sample and that of the reference standards used, the aqueous portion of the mobile phase was lowered slightly to below the 25% stated in the method guidelines in order to elute the reference standards and sample within a reasonable timeframe. As the result is reported as a limit value this was considered not to impact the result.

Conclusions:
Under the conditions of the study, the partition coefficient of the test item has been determined to be greater than 2.51 x 10^9, log10 Pow >9.4.
Executive summary:

Under the conditions of the study, the partition coefficient of the test item has been determined to be greater than 2.51 x 109, log10 Pow > 9.4, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and Method 830.7570 of the OCSPP Guidelines, August 1996.

Description of key information

Under the conditions of the study, the partition coefficient of the test item has been determined to be greater than 2.51 x 109, log(10) P(ow) > 9.4, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and Method 830.7570 of the OCSPP Guidelines, August 1996.

Key value for chemical safety assessment

Log Kow (Log Pow):
9.4

Additional information