3-mercaptopropane-1,2-diol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Remarks:

study was conducted prior to the GLP legislation

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-mercaptopropane-1,2-diol

EC Number:

202-495-0

EC Name:

3-mercaptopropane-1,2-diol

Cas Number:

96-27-5

Molecular formula:

C3H8O2S

IUPAC Name:

3-sulfanylpropane-1,2-diol

Test material form:

liquid: viscous

Specific details on test material used for the study:

Batch 297-1382

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

BW: 200-300 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Remarks:

except for 0.05 and 0.25 mg/kg dose, which were administered as 1% solution in water

Details on oral exposure:

animals were fasted for 24 h before dosing

Doses:

0.05, 0.25, 0.50, 1.00, 5.00 mL/kg bw
62, 312, 623, 1247, 6234 mg/kg bw (using density of 1.25 g/mL)

No. of animals per sex per dose:

5 (3m / 2f)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

Probit analysis (Miller & Tainter, Proc Soc Biol Med 57, 261 (1944))

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

0.52 mL/kg bw

Based on:

test mat.

Effect levels 2

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

648 mg/kg bw

Based on:

test mat.

Mortality:

mg/kg bw dead total mortality
62 0 5 0%
312 0 5 0%
623 2 5 40%
1247 5 5 100%
6234 5 5 100%

Clinical signs:

other: not reported

Gross pathology:

not reported

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

Based on an LD50 of 648 mg/kg bw, monothioglycerol should be classified as Acute Tox 4 - H302: Harmful if swallowed