Registration Dossier
Registration Dossier
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EC number: 201-739-3 | CAS number: 87-32-1
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- N-Acetyl-DL-tryptophan
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: bulk
- Reference substance:
- N-Acetyl-DL-tryptophan
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT assessment of N-Acetyl-DL-tryptophan (CAS 87-32-1) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2014).
Persistence
Based on experimental findings N-Acetyl-DL-tryptophan (CAS 87-32-1) is readily biodegradable (74.6% after 28 d, O2 consumption corrected for nitrification, 301 F). Thus, the substance does not meet the screening criterion for persistence and is therefore not P or vP.
Bioaccumulation
The log Kow of N-Acetyl-DL-tryptophan (CAS 87-32-1) is very low (< -1.7, pH 7, 23 °C, OECD 107). Therefore, the substance does not meet the screening criterion for bioaccumulation and is therefore not B or vB.
Toxicity
The available aquatic effect concentration of N-Acetyl-DL-tryptophan (CAS 87-32-1) for chronic toxicity is ≥ 0.1 mg/L (algae) and is > 0.1 mg/L for acute toxicity (fish, aquatic invertebrates and algae). Furthermore, the substance is readily biodegradable and has a log Kow < 4.5. Therefore, the criteria set out in Annex XIII of Regulation (EC) No 1907/2006 are not met and the substance is not considered to meet the T criterion.
In conclusion, the substance is not PBT/vPvB.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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