Peptones, soybean

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-06-05 to 2018-11-22

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: Knudsen cell

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0.003 Pa

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0.004 Pa

Test no.:

#3

Temp.:

50 °C

Vapour pressure:

0.001 Pa

Effusion method: Vapour pressure balance

The vapour pressure was measured in the temperature range of 78 to 123 °C. Due to the fact that range of the molecular mass of the test item was very wide, the vapour pressures
were calculated for the mean molecular weight of 1123.3 g/mol. The measured vapour pressure values together with the measured temperatures are listed below:

 

Results of the Effusion method

No.	Temperature / °C	Vapour pressure for M=1123.3 g/mol/Pa
1	78	2.50 x10E-2
2	87	3.70 x 10E-2
3	92	4.53 x 10E-2
4	102	6.52 x 10E-2
5	113	7.72 x 10E-2
6	123	1.13 x 10E-1

 

From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation was derived:

 

A= 4.0932

B= -1939.31

C = 273.15

 

Calculated vapour pressure values for 20, 25 and 50 °C

Temperature /°C	Vapour pressure for M=1123.3 g/mol/Pa
20	3.00 x 10E-3
25	3.88 x 10E-3
50	1.24 x 10E-3

 

Conclusions:

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C to be 3.0x10E-3 Pa, 3.88x10E-3 Pa and 1.24x10E-3 Pa, respectively.

Executive summary:

 A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure was measured in the temperature range of 78 to 123°C using the effusion method (vapour pressure balance). All measured values showed good reproducibility, giving relative standard deviations of less than 25 %, and good correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated for the temperatures 20, 25 and 50°C to be 3.0 x10E-3 Pa, 3.88x10E-3 Pa and 1.24x10E-3 Pa, respectively.

Description of key information

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C to be 3.0x10E-3 Pa, 3.88x10E-3 Pa and 1.24x10E-3 Pa, respectively.

Key value for chemical safety assessment

Vapour pressure:

0.003 Pa

at the temperature of:

20 °C

Additional information

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item (reference 4.6 -1). The vapour pressure was measured in the temperature range of 78 to 123°C using the effusion method (vapour pressure balance). All measured values showed good reproducibility, giving relative standard deviations of less than 25 %, and good correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated for the temperatures 20, 25 and 50°C to be 3.0 x10E-3 Pa, 3.88x10E-3 Pa and 1.24x10E-3 Pa, respectively.