Registration Dossier
Registration Dossier
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EC number: 947-662-5 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report. Test item compostion unknown
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Reaction Products of Naphthalene-1,6-diol with 2-Benzofuran-1,3-dione, sodium salt
- EC Number:
- 947-662-5
- Molecular formula:
- C28H14Na2O5
- IUPAC Name:
- Reaction Products of Naphthalene-1,6-diol with 2-Benzofuran-1,3-dione, sodium salt
- Test material form:
- solid
- Details on test material:
- Name of the test substance used in the study report: Scheckfarbstoff AS
The purity is stated as 100% of the drawn chemical structure in the order sheet. (Chemical structure is identical to the main component of the UVCB, CAS 6359-10-9)
The substance is stated to be a sales product.
The water solubility is indicated to be 20g/L. No information on pH is provided.
Constituent 1
- Specific details on test material used for the study:
- Name of the test substance used in the study report: Scheckfarbstoff AS
Content: 100%
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 28.4 g, females 26.0 g
The animals were offered a standardized animal laboratory diet.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- 0.5% aqueous CMC preparation
Form of application: suspension
Concentrations used: 2, 5.62, 7, 14.7 and 20% (w/v) - Doses:
- 200, 562, 700, 2470 and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 900 mg/kg bw
- Mortality:
- 200 mg/kg: no deaths; 562 mg/kg: 1/5 males after 14 days; 700 mg/kg: 1/5 females and 2/5 males after 14 days; 1470 mg/kg: 4/5 females and 5/5 males after 14 days; 2000 mg/kg: all animals died within 24 hours
- Clinical signs:
- Protracted death, poor general state and weight loss; staggering, trembling, twitching, spastic gait, in some animals convulsions
- Gross pathology:
- Animals that died: intra-abdominal stain
Sacrificed animals: very fine intra-abdominal deposits of the test substance
Applicant's summary and conclusion
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