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EC number: 947-662-5 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- less reporting details
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction Products of Naphthalene-1,6-diol with 2-Benzofuran-1,3-dione, sodium salt
- EC Number:
- 947-662-5
- Molecular formula:
- C28H14Na2O5
- IUPAC Name:
- Reaction Products of Naphthalene-1,6-diol with 2-Benzofuran-1,3-dione, sodium salt
- Test material form:
- solid
- Details on test material:
- Name of the test substance used in the study report: Scheckfarbstoff AS
The purity is stated as 100% of the drawn chemical structure in the order sheet. (Chemical structure is identical to the main component of the UVCB, CAS 6359-10-9)
The substance is stated to be a sales product.
The water solubility is indicated to be 20g/L. No information on pH is provided.
Constituent 1
- Specific details on test material used for the study:
- Name of the test substance used in the study report: Scheckfarbstoff AS
Content: 100%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 235 g, females 185 g
The animals were offered a standardized animal laboratory diet.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- 0.5% aqueous CMC preparation
Form of administration: suspension
Concentrations used: 21.5 and 50% (w/v) - Doses:
- 2150 and 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: One female died at 5000 mg/kg bw.
- Mortality:
- 2150 mg/kg: no deaths; 5000 mg/kg: 1/5 females after 24 hours
- Clinical signs:
- other: Poor general state for a short period of time on the 1st day of the study with unspecific signs.
- Gross pathology:
- Sacrificed animals: organs: no abnormalities detected
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
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