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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
less reporting details
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Reaction Products of Naphthalene-1,6-diol with 2-Benzofuran-1,3-dione, sodium salt
EC Number:
947-662-5
Molecular formula:
C28H14Na2O5
IUPAC Name:
Reaction Products of Naphthalene-1,6-diol with 2-Benzofuran-1,3-dione, sodium salt
Test material form:
solid
Details on test material:
Name of the test substance used in the study report: Scheckfarbstoff AS
The purity is stated as 100% of the drawn chemical structure in the order sheet. (Chemical structure is identical to the main component of the UVCB, CAS 6359-10-9)
The substance is stated to be a sales product.
The water solubility is indicated to be 20g/L. No information on pH is provided.
Specific details on test material used for the study:
Name of the test substance used in the study report: Scheckfarbstoff AS
Content: 100%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
Mean body weight: males 235 g, females 185 g
The animals were offered a standardized animal laboratory diet.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
0.5% aqueous CMC preparation
Form of administration: suspension
Concentrations used: 21.5 and 50% (w/v)
Doses:
2150 and 5000 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: One female died at 5000 mg/kg bw.
Mortality:
2150 mg/kg: no deaths; 5000 mg/kg: 1/5 females after 24 hours
Clinical signs:
other: Poor general state for a short period of time on the 1st day of the study with unspecific signs.
Gross pathology:
Sacrificed animals: organs: no abnormalities detected

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS