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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data appear solid, but report lacks details consistent with a guideline study.

Data source

Reference
Reference Type:
publication
Title:
Final Report on the Safety Assessment of Triethanolamine, Diethanolamine and Monoethanolamine.
Author:
Cosmetic Ingredient Review (CIR)
Year:
1983
Bibliographic source:
J. Am. Coll. Toxicol. 2 (7): 173-235.

Materials and methods

Principles of method if other than guideline:
Guideline followed: Not specified.
GLP compliance:
no
Test type:
other: Not specified.

Test material

Constituent 1
Reference substance name:
2,2',2''-nitrilotriethanol
EC Number:
203-049-8
EC Name:
2,2',2''-nitrilotriethanol
Cas Number:
102-71-6
Molecular formula:
C6H15NO3
IUPAC Name:
2,2',2''-nitrilotriethanol
Test material form:
not specified
Specific details on test material used for the study:
Identity: Triethanolamine
CAS Number: 102-71-6
Purity: 91.8% triethanolamine; 6% diethanolamine

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Number of animals/sex/dose: Not specified.

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Undiluted TEA (containing slighlty more than 6% DEA) were applied to the intact skin of three rabbits and to the abraded skin of three rabbits. The test was a 24h closed patch test and the TEA was applied to yield a rabbit exposure of 2 g/kg actual TEA.
Duration of exposure:
The test was a 24 h closed patch test.
Doses:
The test was a 24 h closed patch test and the TEA was applied to yield a rabbit exposure of 2 g/kg of actual TEA.
No. of animals per sex per dose:
Not specified.
Control animals:
not specified
Details on study design:
The animals were observed for 14 days.
Statistics:
Not specified.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 other: g/kg
Based on:
test mat.
Mortality:
None
Clinical signs:
91.8% TEA elicited moderate erythema and no edema at 24h with recovery at treated sites by Day 10.
Body weight:
All rabbits gained weight.
Gross pathology:
Not specified.

Applicant's summary and conclusion

Conclusions:
LD50 is greater than 2 g/kg.
Executive summary:

Triethanolamine (TEA, purity: 91.8 % triethanolamine; 6% diethanolamine) was administered dermally to rats. The acute dermal LD50 is >2 g/kg. Limited information is available and GLP and the study validity are not specified. However, the study is considered reliable but lacking in details consistent with a guideline study requirements.