Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction product of 2-hydroxyethylacrylate with imidazole
EC Number:
926-135-3
Cas Number:
1181222-25-2
Molecular formula:
not applicable
IUPAC Name:
Reaction product of 2-hydroxyethylacrylate with imidazole
Test material form:
liquid: viscous

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
23 °C
pH:
6
Remarks on result:
other: pH value of the water used for the preperation of the eluent

Any other information on results incl. tables

Result:

As the retention time of the test item peak was below the one

of 2-butanone (log Pow = 0.3), the log Pow is estimated to be < 0.3.

Solubility in n-octanol

Additionally the solubility of the test item in n-octanol was visually

tested. The test item is miscible at room temperature

(23 °C) and at T = 20.0 °C ± 0.5 °C with n-octanol in any ratio.

Applicant's summary and conclusion

Conclusions:
As the retention time of the test item peak was below the one
of 2-butanone (log Pow = 0.3), the log Pow is estimated to be
< 0.3.

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