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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 27 September 2017 to 06 March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to other study
Reason / purpose:
reference to other study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method
Key result
Water solubility:
0.108 mg/L
Temp.:
20 °C
pH:
> 5.8 - < 6
Water solubility:
> 0.103 - < 0.114 mg/L
Temp.:
20 °C
pH:
5.8
Water solubility:
> 0.104 - < 0.111 mg/L
Temp.:
20 °C
pH:
6
Details on results:
In the preliminary test, the content of test item dissolved in the water sample was <10mg/l

The coefficient of variation at each flow rate was lower than 30%. It was demonstrated that the system was equilibrated at all flow rates.

The maximum difference on the mean values of the samples at both flow rates was also lower than 30%. Based on this, the water solubility of the test item is given as the means value of these measurements.

The turbidity of the eluates was lower than 0.2 NTU. According to this, no undissolved particles were detected in the eluates. No test item was detected in the samples from the blank column.

Conclusions:
The water solubility of the test item is 0.108 mg/l at 20°C and pH between 5.8 up to 6.0
Executive summary:

The water solubility of

the test item was determined according to recognised guidelines and under GLP. No deviation from the guideline was observed during the study.

Based on the results obtained in the preliminary test, the column elution method was used for the test item water solubility measurement.

The water solubility of the test item is 0.108 mg/l at 20°C and pH between 5.8 up to 6.0

Description of key information

The water solubility of the test item was detemined in a key study of Klimisch validity 1 performed according to recognised guidelines and in compliance with GLP (Brekelmans, 2018).

No deviation from the guideline was observed in the study.

Key value for chemical safety assessment

Water solubility:
0.108 mg/L
at the temperature of:
20 °C

Additional information

Based on the water solubility at 20°C, the test item is considered as slightly soluble.