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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 27 September 2017 to 06 March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to other study
Related information:
Composition 1
Reason / purpose:
reference to other study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
2004
Deviations:
no
Qualifier:
according to
Guideline:
other: EC Guideline A.24. Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method.
Version / remarks:
2016
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Test material information:
Composition 1
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
2.4
Temp.:
35 °C
pH:
2
Key result
Type:
log Pow
Partition coefficient:
2.4
Temp.:
35 °C
pH:
7
Details on results:
Due to the presence of two phenol groups, the determination of the partition coefficient was performed at two pH values: pH 2 and pH 7. Indeed, according to the guidelines, the determination of the partition coefficient should be performed on its non-ionized form and preferably also for the dissociated form. At pH 2, the test item is present in its non-ionized form.
Conclusions:
The partition coefficient (log pow) of the test item is 2.4 at pH 2 and also at pH 7.
Executive summary:

The partition coefficient (Pow) of the test item was determined with the HPLC method according to recognised guidelines and in complaince with GLP (Brekelmans, 2018). No deviation from the guidelines was observed during the test.

The test item log Pow is 2.4 at pH 2 and 7. Based on these results it can be expected that the test item is not potentially bioaccumulable.

Description of key information

The partition coefficient of the test item was detemined in a key study of Klimisch validity 1 performed according to recognised guidelines and in compliance with GLP (Brekelmans, 2018).

No deviation from the guideline was observed in the study.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.4
at the temperature of:
35 °C

Additional information

Based on its log Pow value, the test item is considered not to possess a potential for bioaccumulation.