Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 February 2018 - 21 February 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed according to OECD 102 guideline and EU method A.1, under GLP, without deviation and with certificate of analysis included.
Cross-referenceopen allclose all
Reason / purpose:
reference to other study
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
not specified
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
not specified
GLP compliance:
yes (incl. certificate)
Remarks:
2017-01-10
Type of method:
differential scanning calorimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
impurity
Type:
impurity
Test material form:
liquid
Details on test material:
Batch No.: 190971
Purity: 95.5% (sum of the two main constituents)
Name of test material (as cited in study report): REACTION MASS OF TOLUENE AND 2-VINYL-1,3-DIOXOLANE
Physical state: colourless liquid
Storage conditions: +2°C to +8°C, under nitrogen and protected from light
Expiry date: 10 April 2018

Results and discussion

Melting / freezing pointopen allclose all
Melting / freezing pt.:
< -20 °C
Atm. press.:
ca. 975 hPa
Decomposition:
no
Remarks on result:
other: First determination
Remarks:
No melting point was observed from -20.0°C
Melting / freezing pt.:
< -20 °C
Atm. press.:
975 hPa
Decomposition:
no
Remarks on result:
other: Second determination
Remarks:
No melting point was observed from -20.0°C
Melting / freezing pt.:
< -20 °C
Atm. press.:
975 hPa
Decomposition:
no
Remarks on result:
other: Third determination
Remarks:
No melting point was observed from -20°C
Key result
Melting / freezing pt.:
< -20 °C
Atm. press.:
ca. 1 atm
Decomposition:
no
Sublimation:
no
Remarks on result:
other: Final values - Mean of the three determinations

Any other information on results incl. tables

Pre-study:

Peaks assigned to the boiling of the substance were observed and measurement was stopped at 175°C.

Temperature corresponding to these peaks were used to create the following temperature program:

Temperature program:

 Step

 Initial

temperature

(°C)

 Final

temperature

(°C)

 Heating rate

(°C/min)

 Duration

(min)

Furnace

atmosphere 

 Rate*

(mL/min)

 Liquid

nitrogen

cooling

 1  20  -120  10  14  He  60  Yes
 2  -120  -120  0  5  He  60  NO
 -120  160  10  28  He  60  NO

 *Gas injection rate in the furnace.

First Determination:

Mass taken: 14.96 mg

Results:

No melting point was observed from -20.0°C.

Atmospheric pressure: 975.0 hPa.

Second Determination:

Mass taken: 11.08 mg

Results:

No melting point was observed from -20.0°C.

Atmospheric pressure: 975.0 hPa.

Third Determination:

Mass taken: 9.58 mg

Results:

No melting point was observed from -20.0°C.

Atmospheric pressure: 975.0 hPa.

Applicant's summary and conclusion

Conclusions:
According to guideline OECD 102 and method EU A.1, no melting point of substance REACTION MASS OF TOLUENE AND 2-VINYL-1,3-DIOXOLANE was observed from - 20°C.
Executive summary:

A study was performed to determine the melting point/range of test item REACTION MASS OF TOLUENE AND 2-VINYL-1,3-DIOXOLANE.

The method used was Differential Scanning Calorimetry (DSC) and the test was according to Regulation EC No. 440/2008, method A.1 and OECD Test Guideline 102 ''Melting Point/Melting Range''.

In this method, two crucibles were put in the apparatus furnace under inert atmosphere (helium) at atmospheric pressure. One crucible contained the test item, the other was empty and considered as the reference. A specific temperature program was applied.

The crucibles were linked to two thermocouples fixed on the TG-DSC sample carrier. Heat flow differences between the two crucibles and mass variation were recorded on a thermogram.

A cooling system using liquid nitrogen allowed experiments with low temperatures down to -120°C.

Three trials were conducted and corresponding thermograms were obtained, giving us the following results:

 

 Trial  Melting point/range  Ambient pressure
 1  < -20 °C  975.0 hPa
 2  < -20 °C  975.0 hPa
 3  < -20 °C  975.0 hPa

The melting point of the Indium respects the checking cards limits (156.5°C for a reference value of 156.6°C) so as its enthalpy (30.7 J/g for a reference value of 28.6 J/g).

The melting point of the substance was determined as < -20.0°C.