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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
2,2',2''-nitrilotriethanol
EC Number:
203-049-8
EC Name:
2,2',2''-nitrilotriethanol
Cas Number:
102-71-6
Molecular formula:
C6H15NO3
IUPAC Name:
2,2',2''-nitrilotriethanol
Test material form:
liquid: viscous
Specific details on test material used for the study:
- Name of test material (as cited in study report): Triethanolamine derived from NH3 and Triethanolamine derived from DEA
- Lot-No.: test substance from NH3: jefferson 50303 and test substance from DEA: 2H1763
- Analytical purity: test substance derived from NH3: 91.8 %;
- Analytical purity: test substance derived from DEA: 88.1 %;
- Impurities: both test substances contain DEA as a major impurity of about 6.5 %, the DEA derived test substance additionally includes TEA-1EO at 4.4 %

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Intact and abraded skin was tested.
Doses:
- DEA-derived test substance: 2000 mg/kg bw
- NH3-derived test substance: 2000 mg/kg bw
No. of animals per sex per dose:
- DEA-derived test substance: 3 animals tested with intact skin and 3 animals tested with abraded skin (6 in total)
- NH3-derived test substance: 3 animals tested with intact skin and 3 animals tested with abraded skin (6 in total)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occurred in all test groups.
Clinical signs:
other: - DEA-derived test substance: moderate erythema at 24 hours (intact and abraded skin) returning to normal on day 10 - NH3-derived test substance: mild erythema at 24 hours (intact and abraded skin) returning to normal on day 6

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met