Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: oral
Adequacy of study:
other information

Data source

Reference Type:
other: Body responsible for the test

Materials and methods

Test guideline
according to guideline
other: 92/69/EWG, B.1; OECD 401
GLP compliance:
Test type:
standard acute method
Limit test:

Test animals

other: rat, Wistar, HOE WISKf (SPF71)

Administration / exposure

other: Sesamöl (Ph. Eur. III) "ENGLISH" Sesame oil (Ph. Eur. III)

Results and discussion

Effect levels
Dose descriptor:
Effect level:
> 2 000 mg/kg bw
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Während der Studie traten keine Todesfälle auf. Die
folgenden Symptome wurden beobachtet:

Hochbeiniger, unkoordinierter ataxischer Gang, reduzierte
Spontanaktivität, eingezogene Flanken und Bauchlage.

Nach 2 Tagen waren die Symptome reversibel. Die
Körpergewichtsentwicklung war nicht beeinträchtigt.


No mortalities occurred during the study. The following
symptoms were observed:

High-legged gait, uncoordinated, ataxic gait, reduced
spontaneous activity, drawn-in flanks and ventricumbency.
The symptoms were reversible after 2 days. The body-weight
gain was not impaired.
Gross pathology:
Effects on organs:
Die am Ende der Studie getöteten Tiere zeigten keine
makroskopisch sichtbaren Veränderungen.


The animals killed at the end of the study did not exhibit
any macroscopically visible changes.

Applicant's summary and conclusion

Interpretation of results:
not classified
Migrated information Criteria used for interpretation of results: EU