Furan, 2-(ethoxymethyl)tetrahydro-

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21 days

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Published data described by OECD for SIDS review for alcohol metabolite.

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Remarks:

Report demonstrating equivalent metabolic processes for alcohol and ether.

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2005

Report date:

2005

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 211 (Daphnia magna Reproduction Test)

Principles of method if other than guideline:

Performed as limit test in view of low toxicity observed in preliminary work

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Tetrahydrofurfuryl alcohol

EC Number:

202-625-6

EC Name:

Tetrahydrofurfuryl alcohol

Cas Number:

97-99-4

Molecular formula:

C5H10O2

IUPAC Name:

Tetrahydrofurfuryl alcohol

Specific details on test material used for the study:

Purity = 99.480%

Sampling and analysis

Analytical monitoring:

yes

Details on sampling:

The test concentrations were measured for both renewal and old test solution at the start of the test and 1st, 7th, 8th, 14th and 15th day.

Test solutions

Vehicle:

no

Details on test solutions:

Control and 100 mg/l nominal

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

< 24 hours old at start of study

Study design

Test type:

semi-static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

21 d

Test conditions

Hardness:

Total hardness (as CaCO3): 245 - 270 mg/L

Test temperature:

Water Temperature: 20+/-1C

pH:

7.6 - 8.3

Dissolved oxygen:

7.3 - 8.6mg/ml

Nominal and measured concentrations:

Nominal 100 mg/l; reported recoved > 93%

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Details on results:

LC50 (21days) > 95.1 mg/L (parental mortality) (mc)
EC50 (21days) > 95.1 mg/L (mc)
NOEC (21days) > 95.1 mg/L
LOEC (21days) > 95.1 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

Substance considered to be of low toxicity