Registration Dossier
Registration Dossier
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EC number: 615-086-0 | CAS number: 70225-05-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Conducted to sound scientific principles.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- TRIS(2-ETHYLHEXYL)BENZENE-1,2,4-TRICARBOXYLATE
- Author:
- OECD SIDS
- Year:
- 2 002
- Bibliographic source:
- SIDS initial Assessment Report for Siam 14: TRIS(2-ETHYLHEXYL)BENZENE-1,2,4-TRICARBOXYLATE
- Reference Type:
- publication
- Title:
- Tissue distribution and excretion of tris(2-ethylhexyl)trimellitate in rats
- Author:
- Martis L et al
- Year:
- 1 987
- Bibliographic source:
- J. Toxicol. Envir. Hlth 20, 357-366
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
- EC Number:
- 222-020-0
- EC Name:
- Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
- Cas Number:
- 3319-31-1
- Molecular formula:
- C33H54O6
- IUPAC Name:
- tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
- Reference substance name:
- Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
- IUPAC Name:
- Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
Constituent 1
Constituent 2
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- intravenous
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- TOTM given intravenously accumulated in the liver (72%), lungs and spleen in rats within 24 hours. Biliary excretion, the main elimination route, was slow indicating a potential for accumulation in these target organs.
- Executive summary:
The disposition kinetics of tri-(2-ethylhexyl)trimellitate (TOTM), was studied in rats following intravenous administration of [14C-carbonyl]tri-(2-ethylhexyl)trimellitate using an oil in water emulsion as the vehicle. The distribution half-life, elimination half-life, and clearance values estimated from the plasma concentration of radioactivity data obtained following iv administration of 10.5 mg/kg of TOTM (59.9 muCi/kg), were 46.2 min, 5.34 d, and 40.5 ml/kg h, respectively. Following iv dosage of 15.6 mg/kg of TOTM (28.0 muCi/kg), significant accumulation of radioactivity was found in the liver, lungs, and spleen, with liver accounting for 72% of the administered dosage at 24 h. Excretion of TOTM and its biotransformation products was slow, with 21.3% of the administered radioactivity found in the feces and 2.8% in the urine during the 14-d collection period. Biliary excretion seems to be the major route of elimination of TOTM.
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