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EC number: 615-086-0
CAS number: 70225-05-7
The disposition kinetics of tri-(2-ethylhexyl)trimellitate
(TOTM), was studied in rats following intravenous
[14C-carbonyl]tri-(2-ethylhexyl)trimellitate using an oil
in water emulsion as the vehicle. The distribution
half-life, elimination half-life, and clearance values
estimated from the plasma concentration of radioactivity
data obtained following iv administration of 10.5 mg/kg of
TOTM (59.9 muCi/kg), were 46.2 min, 5.34 d, and 40.5 ml/kg
h, respectively. Following iv dosage of 15.6 mg/kg of TOTM
(28.0 muCi/kg), significant accumulation of radioactivity
was found in the liver, lungs, and spleen, with liver
accounting for 72% of the administered dosage at 24 h.
Excretion of TOTM and its biotransformation products was
slow, with 21.3% of the administered radioactivity found
in the feces and 2.8% in the urine during the 14-d
collection period. Biliary excretion seems to be the major
route of elimination of TOTM.
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