Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 615-086-0 | CAS number: 70225-05-7
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to terrestrial plants - read-across data (2 key studies in lettuce and ryegrass)
Read-across results with surrogate indicate that the submission substance, CAS No. 70225-05-7, is not expected to produce toxicity to terrestrial plants at high soil loading rates (> 8551 mg/kg and >8630 mg/kg).
Key value for chemical safety assessment
Additional information
No terrestrial plant toxicity data are available for the submission substance, CAS No. 70225-05-7, or related trimellitate esters. However, short-term terrestrial plant toxicity studies have been reported for the diisodecyl phthalate (DIDP) (CAS No. 68515-49-1) which can provide some useful read-across assessment for the trimellitates.
As discussed previously, from a structure activity relationship perspective, the long-chain alkyl phthalates and the corresponding long-chain trimellitates are chemically similar or related in that they are benzene dicarboxylic or tricarboxylic acid ester analogs of each other. Hence, in the absence of trimellitate surrogate data, available data for the corresponding phthalate esters of similar chain-length, like DIDP, may be considered as an alternative read-across surrogate to help in estimating the potential terrestrial toxicity of the submission substance, CAS No. 70225-05-7, which is a trimellitate with two C10 and one C13 group). See additional discussion in CSR document.
The toxicity of the read-across surrogate, diisodecyl phthalate (DIDP) (CAS No. 68515-49-1) as measured by effects on emergence or growth to lettuce and ryegrass was evaluated in a 5-day terrestrial plant toxicity test. Results indicated that DIDP had no observed effect on germination of lettuce (Lactuca sativa) or ryegrass (Lolium species) in the 5-day plant toxicity test in natural or artificial soil. The 5-day EC50 values were >8630 mg/kg (dw) in natural soil and > 8551 mg/kg measured (dw) in artificial soil for both plant species. The 5-day NOEC values also were >8630 mg/kg (dw) in natural soil and > 8551 mg/kg measured (dw) in artificial soil for both plant species. Collectively, these findings indicate that the DIDP does not cause acute toxicity to terrestrial plants at high soil concentrations (e.g., as high as 8630 mg/kg (dw).
Based on the above read-across toxicity data, the submission substance, CAS No. 70225-05-7, would not be expected to cause toxicity or adverse effects to terrestrial plants in soil.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
