Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 615-086-0
CAS number: 70225-05-7
Short term and long term toxicity in earthworm - read-across data ( short-term study and long-term study)Read-across findings indicate that the submission substance is not expected to cause short-term or long-term toxicity to earthworms.
No earthworm toxicity data are available for the submission substance.
CAS No. 70225-05-7, or related trimellitate esters. However,
earthworm toxicity data have been reported for the dinonyl phthalate
(DINP) (CAS No. 68515-48-0) and di-isodecyl phthalate (DIDP)(CAS No.
68515-49-1), which can provide some useful read-across assessment for
From a structure activity relationship perspective, the long-chain alkyl
phthalates and the corresponding long-chain trimellitates are chemically
similar or related in that they are benzene dicarboxylic or
tricarboxylic acid ester analogs of each other. The
phthalate substructure (i.e., 1,2-benzenedicarboxylate alkyl ester) is
present within the trimellitate structure (i.e.,
1,2,4-benzenetricarboxylate alkyl ester) structure. From
a toxicological perspective, one would expect trimellitates to be
relatively less toxic than the corresponding phthalate analogs owing to
its lower water insolubililty and bioavailability. Hence,
in the absence of trimellitate surrogate data, available data for the
corresponding phthalate esters of similar chain-length, like DINP or
DIDP, may be considered as an alternative to help in estimating the
potential terrestrial toxicity of the submission substance (CAS No.
70225-05-7) (which is a trimellitate with two C10 and one C13 group).
Read-across results from a 14-day earthworm study (OECD 207) showed that
di-isodecyl phthalate (DIDP) was not acutely toxic and caused no
mortality or adverse effects in earthworms exposed to soil
concentrations as high as 7664 to 8435 mg/kg dw.
In addition, results from a 56-day earthworm reproduction study show
that DINP did not cause any reproductive toxicity at high concentrations
as determined in an artificial soil. The 56-day NOEC
was 982 mg/kg (d.w.) in artificial soil.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again