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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

Long-term chronic toxicity to aquatic invertebrates - 1 key study with read-across trimellitate surrogate, TOTM (CAS No. 3319-31-1).
Based on results of read-across 21-day study in Daphnia magna, the submission substance, CAS No. 70225-05-7, is not expected to produce chronic toxicity to invertebrates at its maximum water solubility.

Key value for chemical safety assessment

Additional information

No long-term aquatic invertebrate toxicity data were available for the submission substance, CAS No. 70225-05-7.  However, read-across data for a structurally related trimellitate ester, tri-2-ethylhexyl trimellitate (TOTM)(CAS No. 3319-31-1) were available to help assess chronic toxicity to invertebrates.


A 21-day chronic survival and reproduction study was conducted with the surrogate, tri-2-ethylhexyl trimellitate (TOTM) in Daphnia magna. The surrogate material, TOTM,. did not cause any adverse effects to the survival-immobilization and reproduction of Daphnia magna under the conditions of the 21 day toxicity test. Adverse effects are not expected at maximum water solubility limits.


Based on the read-across data and their structural chemical similarity, the submission substance, CAS No. 70225-05-7, would not expected to cause chronic toxicity to invertebrates at its maximum water solubility limits. These findings indicate that the trimellitate esters, owing to their low water solubility, are not expected to pose any acute toxicity to daphnids at their maximum water solubility limits.