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EC number: 615-086-0 | CAS number: 70225-05-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity to aquatic invertebrates, 2 key studies (one with submission substance and other with read-across trimellitate surrogate material) . Results of the two studies indicate that the submission substance is not expected to produce acute toxicity to aquatic invertebrates at or below its maximum water solubility limits.
Key value for chemical safety assessment
Additional information
There are direct data forthe ester reaction products of branched tridecanol, isodecanol and trimellitic anhydride (CAS N0. 70225-05-7) in Daphnia magna as well as read-across daphnid data for the tri-2-ethylyhexyl trimellitate (TOTM) surrogate to assess the short-term toxicity to aquatic invertebrates.
The 48-hr EL50 value was determined to be >100 mg/L WAF (nominal loading rates). No immobilization or abnormal behvioral effects were observed at the WAFs tested for the submission substance, CAS No. 70225-05-7. The substance is not expected to cause acute toxicity to Daphnia magna at its maximum water solubility limits. The no-observed effect loading or NOEL was estimated to be >100 mg/L nominal WAF and is expected to be greater than the maximum water solubility limit of the test material.
In addition, read-across Daphnia magna acute toxicity data were available for a structurally related trimellitate surrogate, tri-2-ethylhexyl trimellitate (TOTM) (CAS No. 3319-31-1). The 48 hr EC50 was determined to be > 180 mg/L and the 48 hr NOEC was determined to be > 180 mg/L for the surrogate TOTM material. There were no immobilization reported at the highest test exposure level (i.e., 180 mg/L). The surrogate trimellitate material is not expected to produce acute toxicity at its maximal water solubility level in this test.
Collectively, based on these findings, the submission substance, CAS No. 70225-05-7, would not be expected to produce acute toxicity to invertebrates at its maximal water solubility level. These findings indicate that the trimellitate esters, owing to their low water solubility, are not expected to pose any acute toxicity to daphnids at their maximum water solubility limits.
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