Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-04-30 to 2007-03-28
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
: Backweiging to determine concentration of the substance; pH was not determined;
Principles of method if other than guideline:
The saturated solution of the test substance in water was prepared at temperatures of 25, 40 and 60°C. The saturated solution was filtered and the flow through was dried in a vacuum oven. The test substance was weighed and the concentration was determined.
GLP compliance:
no
Type of method:
other: comparable to flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Type:
impurity
Test material form:
solid: bulk

Results and discussion

Water solubility
Key result
Water solubility:
ca. 45 mg/L
Conc. based on:
test mat.
Temp.:
25 °C
Remarks on result:
not measured/tested

Applicant's summary and conclusion

Conclusions:
The water solubility of MDI-Urone was determined. It is considered to be moderately soluble.
Executive summary:

The water solubility of MDI-Urone was determined with a method equivalent to the OECD guideline 105. The substance was stirred in water at temperatures of 25°C to get a saturated solution. The concentration of the substance was determined by HPLC.

The water solubility of MDI-Urone at 25°C was determined to be 45 mg/l water.