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EC number: 204-024-4 | CAS number: 113-24-6
Table - Measured concentrations
Ratio of solvents(n-Octanol : Water)
Measured concentration inn-octanol phase(µg/mL)
Measured concentration inaqueous phase(µg/mL)
Measured quantity of test item (Mo; Mw)
Total nominal quantity of test item (Ms)
Total quantity of test item (Mo + Mw)
Table - Calculated partition coefficient (Pow) and log Pow
Log Partition coefficient
A study was conducted in accordance with OECD TG 107, Regulation (EC) No 440/2008 method A.8 and OPPTS 830.7550 to determine the partition coefficient of the test item using the shake flask method. A stock solution of known concentration (~ 0.8 g/L) of the test substance in n-octanol, pre-saturated with water, was prepared. The samples were extracted with ultrapure water in 1:1 volume ratio. The phases were separated by centrifugation (4000 rpm, 5 min, 20 °C) and the aqueous phase was diluted with ultrapure water for HPLC analysis. The samples of n-octanol phases were concentrated with ultrapure water, then directly measured by HPLC. The samples of water phases were diluted with ultrapure water before the HPLC analysis. Test vessels with octanol/water mixture in three different ratios were shaken for 5 minutes by hand. Separation of the two phases was achieved by centrifugation at 20 °C (5 min, 4000 rpm). Then the two phases were analysed using HPLC. The partition coefficient (Pow) of the test item in an n-octanol / water two-phase system was determined to be 0.0001 using shake flask method. The logPow was determined to be -3.83 ± 0.055 (95 % confidence interval).
The partition coefficient (Pow) of the test item in an n-octanol / water two-phase system was determined to be 0.0001 using shake flask method. The logPow was determined to be -3.83 ± 0.055 (95 % confidence interval).
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