Registration Dossier
Registration Dossier
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EC number: 203-319-5 | CAS number: 105-65-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- di-isopropyl xanthogen disulphide (DIXD)
- IUPAC Name:
- di-isopropyl xanthogen disulphide (DIXD)
Constituent 1
In vitro test system
- Vehicle:
- other:
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- open
- Preparation of test site:
- abraded
- Vehicle:
- other: 1:1 acetone-diaxane in 13% guinea pg fat
- Controls:
- not required
- Amount / concentration applied:
- One drop of 0.05, 0.1, 0.2 and 0.5% solutions
- Duration of treatment / exposure:
- 1, 1, 2, 6 aplications over a 3 week period.
- Observation period:
- 2 week rest period
- Number of animals:
- 10 males
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Observation
- Basis:
- animal:
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Tests showed a strong irritancy effect.
Any other information on results incl. tables
| 24hr Irr Intact skin | 24hr Irr Abraded skin | ||||
| 5% | Strong | - | |||
| 0.5% | None | - | |||
| 0.2% | - | None |
|||
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
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