Registration Dossier
Registration Dossier
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EC number: 248-319-6 | CAS number: 27203-92-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- HSDB - Tramadol
- Year:
- 2 018
- Bibliographic source:
- Hazardous Substances Data Bank [Internet]. Bethesda (MD): National Library of Medicine (US). Available from: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not specified
Test material
- Reference substance name:
- Tramadol
- EC Number:
- 248-319-6
- EC Name:
- Tramadol
- Cas Number:
- 27203-92-5
- Molecular formula:
- C16H25NO2
- IUPAC Name:
- (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 270 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
LD50, mouse oral = 270 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD50 of tramadol , as determined in mouse by oral route, is 270 mg/kg.
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