Registration Dossier

Administrative data

Description of key information

LD50, rat oral = 228 mg/kg

LD50, mouse oral = 270 mg/kg

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
according to
Guideline:
other: not specified
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
270 mg/kg bw
Based on:
test mat.

LD50, mouse oral = 270 mg/kg

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
LD50 of tramadol , as determined in mouse by oral route, is 270 mg/kg.
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
according to
Guideline:
other: not specified
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
228 mg/kg bw
Based on:
test mat.

LD50, rat oral = 228 mg/kg

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
LD50 of tramadol , as determined in rat by oral route, is 228 mg/kg.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification