Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 619-490-8 | CAS number: 303186-36-9
Endpoint summary
Administrative data
Description of key information
One eye and one skin irritation study were conducted with the test item. In both studies no irritation was observed after 24, 48 and 72 hours.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
In a primary dermal irritation study (NUMBER), young adult New Zealand
White rabbits (3 females) were dermally exposed to 0.5 g of moistened
test material (NAME) for 4 hours under semiocclusive conditions. Animals
then were observed 1, 24, 48 and 72 hours, as well as 7 days after
treatment. No erythema and no edema irritation were observed within the
course of the observation period. The cumulative irritation score was
0.00 based on the DRAIZE scheme indicating no irritant potential. In
this study, NAME is not a dermal irritant.
Eye irritation:
In a primary eye irritation study (NUMBER) 0.1 g of NAME was instilled into the conjunctival sac of the left eye of young adult New Zealand White rabbits (3 females). Animals then were observed 1, 24, 48 and 72 hours, as well as 7 days after treatment. No signs of irritation were observed at the cornea or iris within the course of the observation period. The cumulative irritation score of NAME was 0.00 based on the DRAIZE scheme indicating no irritant potential. In this study, NAME is not an eye irritant.
Justification for classification or non-classification
Skin irritation:
Based on the results obtained the cumulative irritation score of NAME was 0.00 according to the DRAIZE scheme indicating no irritant potential. Therefore, NAME is classified as not irritating according to EU Directive 67/548/EC amended and repealed by EU Regulation No. 1272/2008 and CLP.
Eye irritation:
Based on the results obtained the cumulative irritation score of NAME was 0.00 according to the DRAIZE scheme indicating no irritant potential. Therefore, NAME is classified as not irritating according to EU Directive 67/548/EC amended and repealed by EU Regulation No. 1272/2008 and CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
