4-(α,α-dimethylbenzyl)phenol

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)

Deviations:

no

GLP compliance:

yes

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: General Electric Company, Sample Reference No. 2000 0863
- Purity: 98-100%

Analytical monitoring:

not required

Vehicle:

no

Test organisms (species):

other: Bacterial seed (Polyseed)

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

28 d

Nominal and measured concentrations:

Nominal: 18.0 +/- 3 mg/L

Reference substance (positive control):

yes

Remarks:

Sodium Acetate

Key result

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

18 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: No effect in Toxicity Control

Table 1:Oxygen Determinations over 28-Day Incubation Period         

Bottle Contents	Dissolved Oxygen (mg/L)
	Day 0	Day 7	Day 14	Day 21	Day 28
Test Control	7.7	7.3	7.3	7.0	6.9
	7.7	7.4	6.9	7.1	6.9
Bottle Contents	Dissolved Oxygen (mg/L)
	Day 0	Day 7	Day 14	Day 21	Day 28
Test Substance: PCP	7.7	7.6	7.1	7.3	7.0
	7.7	7.6	7.2	7.1	6.8
Procedure Control: Sodium Acetate	7.7	3.2	3.2	3.0	2.6
	7.7	3.6	3.1	3.0	3.0
Toxicity Control: Sodium Acetate and PCP	7.7	3.5	3.6	3.0	3.7

Table 2: Kinetics for test substance

Day	% Dmean of PCP	% Dmean of Reference Substance
0	0.0	0.0
7	-0.4	72.0
14	-0.1	72.0
21	-0.2	74.0
28	+0.1	75.0

Validity criteria fulfilled:

yes

Conclusions:

In an OECD Test Guideline 301D study, a nominal concentration of 18 mg/L p-cumylphenol did not adversely affect the biodegradation of the positive control substance (Sodium Acetate) in the toxicity control study.

Executive summary:

A concentration of 18 mg/L p-cumylphenol resulted in no adverse effects to the biodegradation of Sodium Acetate in the toxicity control of a ready biodegradability study.

Description of key information

A concentration of 18 mg/L p-cumylphenol resulted in no adverse effects to the biodegradation of Sodium Acetate in the toxicity control of a ready biodegradability study.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:

18 mg/L