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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The result was obtained from a publically available source which has been subject to peer-review and in which the original data sources are traceable

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1992
Reference Type:
other: Database
Title:
3-Chloropropane-1,2-diol
Year:
2000
Bibliographic source:
IUCLID Dataset, ESIS, Euroepan Chemical Bureau

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
26-24-2
IUPAC Name:
26-24-2
Constituent 2
Reference substance name:
3-Chloro-1,2-propanediol
IUPAC Name:
3-Chloro-1,2-propanediol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Details on inhalation exposure:
Groups of 10 male and 5 female rats were exposed.
Duration of treatment / exposure:
14 days
Frequency of treatment:
6 hours/day, 5days/week
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
1ppm
Basis:

Remarks:
Doses / Concentrations:
4ppm
Basis:

Remarks:
Doses / Concentrations:
18ppm
Basis:

Examinations

Observations and examinations performed and frequency:
Body weights, food consumption, haematological and biochemical parameters, organ weights, gross and microscopic pathology were used to examine the toxicological potential of the substance.

Results and discussion

Results of examinations

Details on results:
Reduced food consumption was observed at 18ppm during the first week of treatment.
Adverse effects on fertility were seen but were not accompanied by histopathological changes in the testes and epididymides.

Effect levels

open allclose all
Dose descriptor:
NOAEL
Effect level:
4 ppm
Based on:
test mat.
Sex:
male/female
Basis for effect level:
clinical signs
Dose descriptor:
LOAEL
Effect level:
18 ppm
Based on:
test mat.
Sex:
male/female
Basis for effect level:
food consumption and compound intake

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
NOAEL = 4ppm.
LOAEL = 18ppm.