Registration Dossier
Registration Dossier
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EC number: 435-560-9 | CAS number: 57090-45-6
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result was obtained from a publically available source which has been subject to peer-review and in which the original data sources are traceable
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
- Reference Type:
- other: Database
- Title:
- 3-Chloropropane-1,2-diol
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset, ESIS, Euroepan Chemical Bureau
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 26-24-2
- IUPAC Name:
- 26-24-2
- Reference substance name:
- 3-Chloro-1,2-propanediol
- IUPAC Name:
- 3-Chloro-1,2-propanediol
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Details on inhalation exposure:
- Groups of 10 male and 5 female rats were exposed.
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- 6 hours/day, 5days/week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
1ppm
Basis:
- Remarks:
- Doses / Concentrations:
4ppm
Basis:
- Remarks:
- Doses / Concentrations:
18ppm
Basis:
Examinations
- Observations and examinations performed and frequency:
- Body weights, food consumption, haematological and biochemical parameters, organ weights, gross and microscopic pathology were used to examine the toxicological potential of the substance.
Results and discussion
Results of examinations
- Details on results:
- Reduced food consumption was observed at 18ppm during the first week of treatment.
Adverse effects on fertility were seen but were not accompanied by histopathological changes in the testes and epididymides.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 4 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
- Dose descriptor:
- LOAEL
- Effect level:
- 18 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- food consumption and compound intake
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOAEL = 4ppm.
LOAEL = 18ppm.
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