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EC number: 435-560-9 | CAS number: 57090-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result was obtained from a publically available source which has been subject to peer-review and in which the original data sources are traceable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No details given.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloropropane-1,2-diol
- EC Number:
- 202-492-4
- EC Name:
- 3-chloropropane-1,2-diol
- Cas Number:
- 96-24-2
- IUPAC Name:
- 3-chloropropane-1,2-diol
- Reference substance name:
- 3-Chloro-1,2-propanediol
- IUPAC Name:
- 3-Chloro-1,2-propanediol
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 4 week study
- Frequency of treatment:
- Every day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 30, 60mg/kg/day
Basis:
- Details on study design:
- Groups of 20 Sprague-Dawley rats of each sex were given 3-chloro-1,2-propanediol at a dose of 0, 30, or 60 mg/kg bw per day by gavage on 5 days per week for 4 weeks. Ten animals of each sex from each group were killed on day 2, and their blood was examined for clinical chemical parameters.
Examinations
- Observations and examinations performed and frequency:
- After 2 days of treatment, the relative weight of the kidney was increased in males at the higher dose and in females at both doses, and on day 25, the relative weights of the kidney, liver, and testis (males at the higher dose) were significantly increased in treated rats.
Histopathological examination revealed chronic progressive nephropathy in eight females at the higher dose and mild tubule dilatation in the testis of three males at the lower dose and seven at the higher dose. One male at the higher dose had severe atrophy of both testes.
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 30 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- clinical signs
- organ weights and organ / body weight ratios
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The substance is toxic by ingestion over prolonged exposure.
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