Registration Dossier

Administrative data

Description of key information

delta-3 -Carene was found to be a skin-sensitiser.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

delta-3 -Carene was tested for skin sensitisation in female Dunkin-Hartley guinea pigs. Groups of guinea pigs (10 or 12/group) received four occluded dermal exposure for 24 hours in scapular region of 50% delta-3-carene followed by challenge dose on the shaven flanks with 10, 3, 1% and vehicle.

 

In the first set of experiments 8 out of 12 and in second, 7 out of 10 animals showed presence of erythema which was considered as positive reaction.

Therefore, delta-3-carene was found to be a skin-sensitiser.


Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

As delta-3-carene showed clear signs of skin sensitisation, it is classified as skin sensitiser category 1B, H317 according to CLP Regulation (EC) N° 1272/2008 and as skin sensitiser "Xi, R43: May cause sensitisation by skin contact" according to Directive 67/548/EEC.