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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Guidance on registration Reference: ECHA-16-G-06-EN Publ.date:November 2016
Practical guide 2: How to report weight of evidence - Reference: ECHA-10-B-05-EN Publ.date: 24/03/2010
"Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals" (ECHA 2008)

Data source

Reference
Reference Type:
publication
Title:
Toxtree - Toxic Hazard Estimation by decision tree approach
Author:
Ideaconsult Ltd
Year:
2016
Bibliographic source:
http://toxtree.sourceforge.net/

Materials and methods

Test guideline
Guideline:
other: REACH Guidance on Qsars and grouping of chemicals R.6 year 2008

Test material

1
Chemical structure
Reference substance name:
Dibromomethane
EC Number:
200-824-2
EC Name:
Dibromomethane
Cas Number:
74-95-3
Molecular formula:
CH2Br2
IUPAC Name:
dibromomethane
Specific details on test material used for the study:
smile: C(Br)Br

Results and discussion

In vitro

Results
Irritation parameter:
other: qualitative estimation
Remarks on result:
no indication of irritation

In vivo

Results
Irritation parameter:
other: qualitative estimation
Remarks on result:
no indication of irritation

Any other information on results incl. tables

  Q1.Melting Point[℃] > 200 No   C(Br)Br
 Q2.LogP>9.0 No   C(Br)Br
 Q3.LogP-3.1 No   C(Br)Br
 Q4.Lipid Solubility0.01 No   C(Br)Br
 Q5.Water Solubility5.0E-6 No   C(Br)Br
 Q6.Water Solubility2.0E-5 No   C(Br)Br
 Q7.MolWeight>650.0 No   C(Br)Br
 Q8.Group C (C,H,O) No   C(Br)Br
 Q9.Group CN (C,H,O,N) No   C(Br)Br
 Q10.Group CNHal (C,H,O,N,F,Cl,Br or I ) No   C(Br)Br
 Q11.Group CNS (C,H,O,N,S) No   C(Br)Br
 Q12.Group CHal (C,H,O,F,Cl,Br or I ) No   C(Br)Br
 Q13.Aliphatic Monoalcohols No   C(Br)Br
 Q14.Aliphatic glycerol monoethers No   C(Br)Br
 Q15.Derivatives of 2-halogen benzoic acids and corresponding alkali salts No   C(Br)Br
 Q16.Halogen benzenes with substituents containing carboxylic acid groups No   C(Br)Br
 Q17.Aliphatic esters of chloro formic acid No   C(Br)Br
 Q18.Chlorinated aliphatic alcohols No   C(Br)Br
 Q19.Diphenyl iodonium salts No   C(Br)Br
 Q20.Derivatives of alpha amino benzene No   C(Br)Br
 Q21.Pyrrolidones No   C(Br)Br
 Q22.Substituted indoles No   C(Br)Br
 Q23. Substituted pyrazoles No   C(Br)Br
 Q24.Aromatic ammonium salts No   C(Br)Br
 Q25.Organic sulphonic salts No   C(Br)Br
 Q26.Thiazoles and thiazolidines No   C(Br)Br
 Q27.Thiazolones No   C(Br)Br
 Q28.Triphenylphosphonium salts No   C(Br)Br
 Q29.Organic phosphinic acids and their derivatives No   C(Br)Br
 Q30.Aliphatic monoalcohols No   C(Br)Br
 Q31.Aliphatic alpha hydroesters No   C(Br)Br
 Q32.Aliphatic carboxylic acids No   C(Br)Br
 Q33.Aromatic ammonium salts No   C(Br)Br
 Q34.Substituted benzoic acid halogenides No   C(Br)Br
 Q35.Aliphatic iso(thio)cyanates No   C(Br)Br
 Q36.Chlorosilanes No   C(Br)Br
 Q37.Mixed oxycarboxysilanes No   C(Br)Br
 Q38.Aliphatic amines No   C(Br)Br
 Q39.Alkali salts of aliphatic alcohols No Class UnknownC(Br)Br

Result: not irritant 

Applicant's summary and conclusion