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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
48 hours
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Justification for type of information:
Performed on marine invertebrate
Guideline study 2008, well reported to GLP
Qualifier:
equivalent or similar to
Guideline:
EPA OPP 72-3 (Estuarine/Marine Fish, Mollusk, or Shrimp Acute Toxicity Test)
Principles of method if other than guideline:
Concentrations of up to 2000 mg/l of the 40% actives material was tested (up to 800 mg/l actives)
GLP compliance:
yes
Specific details on test material used for the study:
Tested as supplied at ca 40% actives in water
Analytical monitoring:
no
Remarks:
Substance supplied in water and considered soluble and stable under the conditions of the test. However, reduced solublity in seawater was reported.
Vehicle:
no
Details on test solutions:
Direct addition to water
Test organisms (species):
other: Acartia tonsa
Details on test organisms:
At the start of the test, the invertebrates were 13 - 15 days old
Test type:
static
Water media type:
saltwater
Limit test:
no
Total exposure duration:
48 h
Test temperature:
20 C
pH:
8.1
Salinity:
31.2 g/l
Nominal and measured concentrations:
0, 200, 355, 632, 1124, 2000 mg/l expressed as 40% solution as supplied (ie maximum 800 mg/l actives)
Reference substance (positive control):
yes
Remarks:
3,5-dichlorophenol at 1 mg/l
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
ca. 1 242 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
40% actives
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
ca. 500 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
< 800 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
coagulation of the embryo
Details on results:
The top dose of 2000 mg/l of substance supplied (800 mg/l actives) reslted in 100% effect
Results with reference substance (positive control):
65% effect at 1 mg/l; considered valid
Validity criteria fulfilled:
yes
Conclusions:
EC50 on marin invertebrate > 100 mg/l.
On this basis, classification is not required

Description of key information

Figure used for CSR

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
500 mg/L

Additional information