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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Study period:
10 March 2017
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Specific details on test material used for the study:
The surface tension of the test material was determined by OECD Test No. 115. It was concluded: The surface tension of a test solution at 90% of the test material saturation solubility in water and at 20°C was 35.0 mN/m. According to this, the test material is considered to be surface active.
Key result
Remarks on result:
not determinable
Remarks:
Direct measurement of the water solubility by OECD Test No. 105 could not be done due to surfactant properties of the test material.
Details on results:
PRELIMINARY TEST
- A test material aliquot of 0.10 grams was shaken after the addition of 100 mL of water. The resulting solution contained some solids, was milky, and exhibited surface foaming. The sample was observed after 72 hours at room temperature and exhibited the same characteristics.

DEFINITIVE TEST
- Samples from the flasks were removed after three days mixing. The samples were cloudy and could not be cleared by filtration (0.2 μm) or centrifugation (9000 rpm) or dilution up to 500 times.
- It is concluded that the test material is surface active and has a solubility of less than 1 g/L.

OBSERVATIONS
- No chemical instability was observed during the test. Indications of water insolubility and surfactant properties were observed.

CONCLUSIONS AND REQUEST FOR EXEMPTION
- The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be done due to surfactant properties of the test material. This is consistent with the surface tension data provided by the Sponsor, after the OECD 105 testing was attempted.
Conclusions:
The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be performed due to surfactant properties of the test material. This is consistent with the surface tension data.
Executive summary:

The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions.

In the preliminary test, 0.10 grams of the test material was shaken after the addition of 100 mL of water. The resulting solution contained some solids, was milky, and exhibited surface foaming. The sample was observed after 72 hours at room temperature and exhibited the same characteristics.

In the definitive test, samples from the flasks were removed after three days mixing. The samples were cloudy and could not be cleared by filtration (0.2 μm) or centrifugation (9000 rpm) or dilution up to 500 times. It is concluded that the test material is surface active and has a solubility of less than 1 g/L.

The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be performed due to surfactant properties of the test material. This is consistent with the surface tension data (35.0 mN/m).

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.

Description of key information

The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be performed due to surfactant properties of the test material. This is consistent with the surface tension data from the OECD 115 test, which reported a surface tension value of 35.0 mN/m at 20C, indicating that the test item has surface active properties.

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.

Key value for chemical safety assessment

Additional information

The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions.

In the preliminary test, 0.10 grams of the test material was shaken after the addition of 100 mL of water. The resulting solution contained some solids, was milky, and exhibited surface foaming. The sample was observed after 72 hours at room temperature and exhibited the same characteristics.

In the definitive test, samples from the flasks were removed after three days mixing. The samples were cloudy and could not be cleared by filtration (0.2 μm) or centrifugation (9000 rpm) or dilution up to 500 times. It is concluded that the test material is surface active and has a solubility of less than 1 g/L.

The test material exhibits surfactant qualities (foaming, stable cloudy solution). Direct measurement of the water solubility by OECD Test No. 105 could not be performed due to surfactant properties of the test material. This is consistent with the surface tension data from the OECD 115 test, which reported a surface tension value of 35.0 mN/m at 20°C.