Registration Dossier
Registration Dossier
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EC number: 947-574-7 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Michaelis constants (Km) and the maximum enzymatic rates (Vmax) are based on reliable experimental results with shorter carbon-chain lactate esters in rat nasal tissue.
- Justification for type of information:
- Information originates from safety assessments of lactate esters.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Safety Assessment of Lactate Esters
- Author:
- Clary J J, Feron V J and van Velthuijsen J A
- Year:
- 1 996
- Bibliographic source:
- Regulatory Toxicology & Pharmacology 27, 88–97 (1998); Article No. Rt971175
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Bogaards, J. J. P., and van Ommen, B. (1992). The in vitro hydrolysis L-lactate eaters by rat nasal olfactory epithelium homogenate. TNO Report V92.339.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dodecyl lactate
- EC Number:
- 228-504-8
- EC Name:
- Dodecyl lactate
- Cas Number:
- 6283-92-7
- Molecular formula:
- C15H30O3
- IUPAC Name:
- dodecyl 2-hydroxypropanoate
- Reference substance name:
- Tetradecyl lactate
- EC Number:
- 215-350-1
- EC Name:
- Tetradecyl lactate
- Cas Number:
- 1323-03-1
- Molecular formula:
- C17H34O3
- IUPAC Name:
- tetradecyl 2-hydroxypropanoate
- Test material form:
- liquid
Constituent 1
Constituent 2
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- other: Km ranges from 0.022 to 0.056 (high affinity)
- Toxicokinetic parameters:
- other: Average Vmax = 481
Any other information on results incl. tables
Toxicokinetic values Km and Vmax for C12 -C14 lactates:
Lactate |
Km |
Vmax |
dodecyl |
0.056 |
476 |
tetradecyl |
0.030 |
483 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results Readily hydrolysis with high enzymatic affinity for C12-C15 lactate esters.
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