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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Michaelis constants (Km) and the maximum enzymatic rates (Vmax) are based on reliable experimental results with shorter carbon-chain lactate esters in rat nasal tissue.
Justification for type of information:
Information originates from safety assessments of lactate esters.

Data source

Reference
Reference Type:
review article or handbook
Title:
Safety Assessment of Lactate Esters
Author:
Clary J J, Feron V J and van Velthuijsen J A
Year:
1996
Bibliographic source:
Regulatory Toxicology & Pharmacology 27, 88–97 (1998); Article No. Rt971175

Materials and methods

Objective of study:
toxicokinetics
Principles of method if other than guideline:
Bogaards, J. J. P., and van Ommen, B. (1992). The in vitro hydrolysis L-lactate eaters by rat nasal olfactory epithelium homogenate. TNO Report V92.339.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dodecyl lactate
EC Number:
228-504-8
EC Name:
Dodecyl lactate
Cas Number:
6283-92-7
Molecular formula:
C15H30O3
IUPAC Name:
dodecyl 2-hydroxypropanoate
Constituent 2
Chemical structure
Reference substance name:
Tetradecyl lactate
EC Number:
215-350-1
EC Name:
Tetradecyl lactate
Cas Number:
1323-03-1
Molecular formula:
C17H34O3
IUPAC Name:
tetradecyl 2-hydroxypropanoate
Test material form:
liquid

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parametersopen allclose all
Toxicokinetic parameters:
other: Km ranges from 0.022 to 0.056 (high affinity)
Toxicokinetic parameters:
other: Average Vmax = 481

Any other information on results incl. tables

Toxicokinetic values Km and Vmax for C12 -C14 lactates:

Lactate

Km

Vmax

dodecyl

0.056

476

tetradecyl

0.030

483

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results Readily hydrolysis with high enzymatic affinity for C12-C15 lactate esters.