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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Calculation of the LC50 of Ceraphyl 41 based on the individual QSAR data for the C12-C15 lactates.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Reason / purpose for cross-reference:
(Q)SAR model reporting (QMRF)
Principles of method if other than guideline:
Calculation of the LC50 of a mixture based on individual LC50 values for the components assuming a similar mode of action.
GLP compliance:
no
Test organisms (species):
other: Fresh water algae
Water media type:
freshwater
Total exposure duration:
96 h
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
0.1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
Ceraphyl 41
Basis for effect:
growth rate
Key result
Duration:
4 d
Dose descriptor:
other: ChV
Effect conc.:
0.091 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate

Description of key information

Value calculated based on ECOSAR estimated individual ErC50 values for the C12, C14 and C16 lactates being the main constituents of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters.

Key value for chemical safety assessment

EC50 for freshwater algae:
0.097 mg/L
EC10 or NOEC for freshwater algae:
0.091 mg/L

Additional information

Estimation of the EC50 ofPropanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl estersfor growth rate of fresh-water algea:

Assumption: Similar Mode of Action for C12-15 lactates

f=fraction of chemical in mixture

Calculation:

f EC50 1/EC50 f/EC50
C12-lactate 0.6 0.378 2.646 1.5873
C14-lactate 0.3 0.086 11.628 3.4884
C16-lactate 0.1 0.019 52.632 5.2632
Σf/EC50 10.339
EC50 - Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters 0.097 mg/L

Estimation of the chronic value of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters for fresh water algae:

Calculated based on QSAR values for Ester Toxicity:

Lactate ChV 1/ChV f f/ChV
Dodecyl lactate 0.235 4.255 0.60 2.5532
Tetradecyllactate 0.074 11.51 0.30 4.0541
Hexadecyllactate 0.023 43.47 0.10 4.3478
Σf/ChV 10.96

ChV ofPropanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters 

0.091

f= estimated average fraction of chemical in mixtures

Based on the analytical results of the 96h algal test with octyl lactate in the referred study, alkyl lactates with C-chains of 8 carbons or more, degrade rapidly due to hydrolysis and bacterial activity.